ANC leader Musalia Mudavadi was designated Prime Cabinet Secretary in President William Ruto’s Tuesday cabinet announcement. After the President and his DP, Rigathi Gachagua, Mr. Mudavadi will be the most senior officer.
 The Roles of the Deputy President
- Deputize for the President in execution of the President’s functions;
- Chair Cabinet Committees;
- Oversee Implementation of Cabinet decisions across all Ministries and State Departments;
- Coordinate Inter-Governmental relations between the National Government and County Governments including Chairing the Inter-Governmental Budget and Economic Council (IBEC);
- Liaison with Constitutional Commissions and Independent Offices in matters that require intervention by the National Government   including budgets, policy formulation  and implementation     of   their recommendations;
- Coordinate the planning and supervise the implementation of development partners funded programs and projects;
- Oversee Public Sector Reforms; and any other function as may be assigned by the President;
| S/NO. | MINISTRY | CABINET SECRETARIES |
| 1. | Â PRIME CABINET SECRETARY | Hon. Musalia Mudavadi
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| •     Assist the President and the Deputy President in the coordination and supervision of Government Ministries and State Departments; •     In liaison with the Ministry responsible for Interior and National Administration, oversee the implementation of National Government policies, programs and projects; •     Chair and Coordinate National Government legislative agenda across all ministries and state departments in consultation with and for transmission to the Party/Coalition Leaders in Parliament; •     Facilitate inter-ministerial coordination of crossfunctional initiatives and programmes; •     Coordinate and supervise the technical monitoring and evaluation of Government policies, programs and projects across Ministries; and •     Perform any other function as may be assigned by the President
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| 2. | INTERIOR & NATIONAL ADMINISTRATION | Hon. Kithure Kindiki |
| 3. | NATIONAL TREASURY AND PLANNING | Prof. Njuguna Ndung’u |
| 4. | WATER, SANITATION AND IRRIGATION | Hon. Alice Wahome |
| 5. | DEFENCE | Hon. Aden Duale |
| 6. | EAST AFRICAN COMMUNITY (EAC), ARID AND SEMI-ARID LANDS (ASALs) AND REGIONAL DEVELOPMENT | Rebecca Miano |
| 7. | FOREIGN AND DIASPORA AFFAIRS | Hon. Alfred Mutua |
| 8. | PUBLIC SERVICE, GENDER AND AFFIRMATIVE ACTION | Hon. Aisha Jumwa Katana |
| 9. | TRADE, INVESTMENT AND INDUSTRY | Moses Kuria |
| 10. | ENVIRONMENT AND FORESTRY | Hon. Soipan Tuya |
| 11. | ROADS, TRANSPORT AND PUBLIC WORKS | Hon. Onesimus Kipchumba Murkomen |
| 12. | TOURISM, WILDLIFE AND HERITAGE | Hon. Penina Malonza |
| 13. | LANDS, HOUSING AND URBAN DEVELOPMENT | Zachariah Mwangi Njeru |
| 14. | HEALTH | Susan Nakhumicha Wafula |
| 15. | AGRICULTURE AND LIVESTOCK DEVELOPMENT | Frankline Mithika Linturi |
| 16. | INFORMATION, COMMUNICATIONS AND THE DIGITAL ECONOMY | Eliud Owalo |
| 17. | EDUCATION | Ezekiel Machogu |
| 18. | ENERGY AND PETROLEUM | Davis Chirchir |
| 19. | YOUTH AFFAIRS, SPORTS AND THE ARTS | Hon. Ababu Namwamba |
| 20. | CO-OPERATIVES AND MICRO, SMALL AND MEDIUM ENTERPRISES (MSME) DEVELOPMENT | Simon Chelugui |
| 21. | MINING, BLUE ECONOMY AND MARITIME AFFAIRS | Hon. Salim Mvurya |
| 22. | LABOUR AND SOCIAL PROTECTION | Hon. Florence Bore |
| CABINET LEVEL PORTFOLIOS | ||||
| 23. | SECRETARY TO THE CABINET | Mercy Wanjau | ||
| 24. | ATTORNEY GENERAL | Justin Bedan Muturi Njoka | ||
| 25. | NATIONAL SECURITY ADVISOR | Monica Juma | ||
| 26. | WOMEN RIGHTS AGENCY ADVISOR | Harriet Chiggai | ||